After last week’s chaos effectively tipped the 2022 college football season into the lead-up, the top-25 teams that were heavy favorites heading into Week 3 might be a little wary on Saturday. With two games between opponents on the schedule and several high-profile non-conference games, league play could shake out a lot before it even starts to close out September.

Most notable was one of the upset losses against the Aggies against Appalachian State on Saturday when No. 13 Miami visited No. 24 Texas A&M. The Hurricanes are looking to make a comeback under first-year coach Mario Cristobal, while Aggies coach Jimbo Fisher is hoping to keep the bench from getting too hot. Speaking of Cristobal, his former team appeared in that Top 25 showdown as No. 25 Oregon hosts No. 12 BYU. The Cougars are feeling themselves after a big home win over Baylor, while the Ducks are still looking to bounce back from their rough showing against Georgia in Week 1.

Also on the slate are No. 6 Oklahoma, rival Nebraska, the firing of Cornhuskers coach Scott Frost, new No. 1 Georgia visiting SEC East rival South Carolina and Auburn taking on No. 22 Penn State in a game featured on CBS. In other words, there will be no shortage of storylines to chew on before Saturday’s release.

Be sure to stick with CBS Sports all day long for college football coverage from the opening kickoff. Let’s take a look at our experts’ picks for the best games in Week 3.

Odds via Caesar’s Sportsbook | All the time Eastern

No. 6 Oklahoma at Nebraska

Noon Fox, fuboTV (Try it for free) — Oklahoma hasn’t faced a Power Five foe under new coach Brent Venables. In fact, the two wins were against teams ranked 95 and 108 by CBS Sports 131. While Nebraska has struggled, the talent jump — along with a new coaching direction — will make this game a little more difficult than early results might suggest. A worse Nebraska team played a seven-point better Oklahoma team last season. Don’t expect things to get out of hand when the game is underway in Lincoln, Nebraska. Pick: Nebraska (+11.5) — Shehan Jayarajah

Follow Oklahoma at Nebraska live on CBS Sports.

No. 1 Georgia at South Carolina

Featured game | South Carolina Gamecocks vs. Georgia Bulldogs

Noon ESPN, fuboTV (Try it for free) — South Carolina’s woes on the offensive line spell offense in this matchup. The Gamecocks are struggling to protect quarterback Spencer Rattler and haven’t had much of a rushing attack in two games. Georgia’s defense doesn’t look like it has fallen at all since five players were taken in the first round of the 2022 NFL Draft, and the Bulldogs may be able to keep South Carolina from reaching double digits. Coach Kirby Smart won’t have a chance to score against a venerable former assistant, but Georgia will have to cover even if its offense keeps things in check. Prediction: Georgia (-24.5) — David Cobb

Follow Georgia in South Carolina on CBS Sports.

No. 22 Penn State at Auburn

Featured game | Auburn Tigers vs Penn State Nittany Lions

3:30 p.m CBS,, CBS Sports App Although Penn State has the bigger win of the two teams, the Nittany Lions don’t look good on the road against Purdue. As a result, I’m not ready to believe the Nittany Lions as road favorites against Auburn even if Auburn doesn’t inspire much confidence. It’s hard to imagine either team being too far ahead of the other in this matchup, with the best defensive units on the field. That makes Auburn and its points an attractive option. Prediction: Auburn (+3) – Tom Fornelli

No. 12 BYU at No. 25 Oregon

Featured game | Oregon Ducks vs. BYU Cougars

3:30 p.m Fox, fuboTV (Try it for free) — Simply put, BYU is better than Oregon in most position groups. Quarterback Jaren Hall flashed his NFL arm in last weekend’s upset against Baylor. The offensive and defensive lines have performed well for the most part over the past three seasons. The secondary played at a high level, with running back Christopher Brooks stepping in well. Conversely, Oregon has gone 1-4 in its last five FBS games and has been outscored 201-90. With wins over Baylor, USC, Utah and four other Power Five foes last year, don’t expect the Cougars to be intimidated by Oregon’s recruiting stars. Prediction: BYU (+3.5) — Jayarajah

UTSA at No. 21 Texas

Featured game | The Texas Longhorns vs. the UTSA Roadrunners

8:00 p.m Longhorn Network — This is a trap game for the Longhorns, but I think they will pull out the win. However, Hudson’s card situation makes me hesitant to pick Texas as a 12.5-point favorite. Card is at his best when playing games with his legs, and the ankle injury can limit his playing time. On top of that, Jeff Traylor’s team has plenty of momentum at one of the Big 12’s premier institutions. Texas gets the win, but the Roadrunners cover. Prediction: UTSA (+12.5) — Austin Nevison

No. 13 Miami at No. 24 Texas A&M

Featured game | Texas A&M Aggies vs. Miami (FL) Hurricanes

9:00 p.m ESPN, fuboTV (Try it for free) — This is going to come down to a battle of the quarterbacks, and the winner of that battle is clear. Tyler Van Dyk is smarter, better guarded and has more weapons than Hines King. Van Dyke and the Hurricanes’ offense set the tempo, making the game playable in the 30s. You can’t hang Texas A&M. A series of mistakes by Texas A&M in the second half would give Miami not only coverage, but an outright win. Prediction: Miami (+5.5) — Barrett Sally

Which college football picks can you be confident about in Week 3, and which favorites will be tough? Visit SportsLine to see which teams will win and coverage of the broadcast — all from a computer model that returned nearly $3,400 in profits over the past six-plus seasons — and find out.

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