Summary: Researchers have found cognitive benefits in older adults who take daily multivitamin-mineral supplements.

Source: Alzheimer’s Association

Alzheimer’s and Dementia: Journal of the Alzheimer’s Association He published “Effects of Cocoa Extract and Multivitamins on Cognitive Function: A Randomized Clinical Trial.”

A three-year study of more than 2,200 older adults found that daily multivitamin-mineral supplementation resulted in statistically significant cognitive benefits.

Cocoa extract had no effect on global perception.

Maria C. Carrillo, PhD, Chief Scientific Officer of the Alzheimer’s Associationsaid of the study: “This is the first positive, large-scale, long-term study showing that multivitamin-mineral supplements in older adults can slow cognitive aging. While the Alzheimer’s Association is encouraged by these results, multivitamins are needed to reduce the risk of cognitive decline in older adults.” We are not ready to recommend the widespread use of vitamin supplements.

“Independent confirmatory studies are needed in larger, more diverse study populations. It is important that future treatments and prevention are effective in all populations.

This shows a pill organizer.
This is the first positive, large-scale, long-term study showing that multivitamin-mineral supplementation in older adults may slow cognitive aging. The image is in the public domain.

“For now and until more information is available, people should discuss all the benefits and risks with their healthcare providers. Dietary supplementsIncluding a multivitamin.

We envision a future in which multiple treatments and risk reduction strategies are available to treat cognitive aging and dementia in multiple ways—such as heart disease and cancer—and can be combined into powerful combination therapies. Factors such as diet and exercise.

So news of aging and cognitive research

Author: Erin Kohnke
Source: Alzheimer’s Association
Contact: Erin Kohnke – Alzheimer’s Association
Image: The image is in the public domain.

Preliminary study: Open Access.
Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial.” by Laura D. Baker et al. Alzheimer’s and dementia


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Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial.

Introduction

Dietary supplements have been suggested for cognitive protection, but supporting evidence is mixed. Cosmos-Mind tested whether daily cocoa extract (containing 500 mg/day flavanols) and placebo and a commercial multivitamin-mineral (MMM) and placebo improved cognition in elderly women and men.

Methods

COSMOS-MIND, a large randomized two-by-two phase 3 3-year trial, assessed cognition by telephone at baseline and annually. The primary outcome was a global cognitive composite composed of mean standardized (z) scores (relative to baseline) from individual tests, Cognitive Status Telephone Interview, Verbal List and History Memorization, Verbal Tracing, Verbal Fluency, Number Span, and Digit Ordering. The primary end point was change in cocoa extract use over 3 years in this composition using an intentional to treat regimen. A pre-specified secondary endpoint was the change in overall MMM adherence at 3 years. Treatment effects were observed for executive function and memory composite scores, and higher risk for cognitive decline in predefined subgroups.

Results

A total of 2262 participants were enrolled (mean age = 73 years; 60% female; 89% non-Hispanic white), and 92% completed baseline and at least one annual assessment. Cocoa extract had no effect on global cognition (mean z-score = 0.03, 95% CI: -0.02 to 0.08; P = .28). Daily MMM supplementation resulted in a statistically significant benefit on global cognition compared to placebo (mean z = 0.07, 95% CI 0.02 to 0.12; P = .007), and this effect was more pronounced in participants with a history of cardiovascular disease.There is no history: 0.06, 95% CI 0.01 to 0.11; History: 0.14, 95% CI -0.02 to 0.31; interaction, noun P = .01). Multivitamin-mineral benefits for memory and executive functions have also been noted. Cocoa extract was not significant for any of the cognitive composites by MVM group interaction.

Discussion

Cocoa extract did not improve cognition. However, COSMOS-Mind provides the first evidence from a large, long-term, functional trial to improve understanding of the potential efficacy of MVM in older adults. Further work is needed to confirm these findings in a more diverse cohort and to identify mechanisms for distinguishing MMM effects.

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