Scientists are working hard to unravel the mysteries of Covid-19, including why some people who haven’t had it before are immune. But experts do not agree on the existence of these so-called “superdodgers” at the moment. Some scientists correctly estimate that some people who have not yet contracted Covid-19. they have He had but didn’t know it because they were completely asymptomatic. Along this line of thinking, UC San Francisco researchers have discovered that some people have a genetic mutation that prevents them from developing symptoms of Covid-19 even when the virus infects their cells. In other words, this mutation does not stop the infection, but it is. will do Prevent symptoms from occurring.
Other scientists, such as Jean-Laurent Casanova and his team at Rockefeller University, are investigating whether there are people who are infected with Covid-19 and were never infected to begin with. ” LAist He explains that while this is unlikely, it happens very rarely.
In human history, scientists have identified only two instances of true viral superdodgers. That is, a certain mutation in their genes makes people completely immune to the virus. To slide off their cells, as Casanova put it, “like water sliding off a glass window.”
To find out, Casanova and his team are currently recruiting participants. LAist explains:
“You fill out an online questionnaire about your exposure to SARS-CoV-2,” he says. And then if you meet the SuperDodger criteria, the team will send you a test kit. They basically spit in a cup and mail it to Casanova and co.
In their research websiteExplain the purpose of the study:
Why do some people get very sick with the coronavirus (Covid-19), others have little or no symptoms, and others never get it? Rather than luck, we think the answer lies in our genome and our immune system. Our genes are small, but powerful and can control our immune system in even the most subtle ways. This may explain why some people seem to be better at fighting off this new virus than others. Immunity can be disrupted by non-genetic mechanisms, thanks to the ‘genetic compass’.
Our mission is to find out why and how our genes affect our immunity to the coronavirus, and how and why immunity is affected by other non-genetic factors. This discovery will allow us to develop new ways to fight this epidemic: better and faster diagnostics, new drugs for treatment and prevention, new vaccination methods and a better understanding of how this infection works in the body.