Cheap, easily available, highly processed foods are bad for us. An interesting new mouse study supported it. Sustainable hypothesis Such as high fat and sugar diets and loss of consciousness Alzheimer’s Are attached.
“Obesity and Diabetes It damages the central nervous system, aggravates mental illness and cognitive decline. We have shown this in our study of mice. Larissa Boborovskaya, a neuroscientist and biochemist at the University of South Australia, says.
The team was looking for a mouse model that could tell us more about the link between Alzheimer’s disease, type 2 diabetes and obesity, and they found a boy.
“As is well known, chronic obesity and type 2 diabetes mellitus are often associated with Alzheimer’s disease, a number of other related diseases, cardiovascular disease and impaired renal function.” The team writes on the new paper.
“Furthermore, obesity and type 2 diabetes are associated with impaired central nervous system function, which can lead to aggravated mental and emotional disorders, including depression, cognitive impairment, and memory loss.”
‘Eating badly’ is mistaken for a Moral declineThis type of discovery may not be helpful for someone with a better eating habits but it could give us more tools to explore this confusing link that the team wanted to see more in mice.
To learn more, the group recommended adult mice a Mutation In human taur protein (P301L), pR5 mice interact with mice (known as wild mice).
Mutations in humans have been linked to Alzheimer’s disease-related neurological defects. Similarly, in mice, the genes provide researchers with a way to accurately identify mechanisms associated with dementia, such as diabetes.
Both groups ate a regular or high-fat diet for 30 weeks. Considering that laboratory mice live for 1.5 years, this is an excellent part of their lives.
The control mice ate a lot of fat for their weight, had a higher risk of developing stress-like behaviors, and had higher levels of vision in the brain. Taw is important because it is a possible protein. hyperphosphorylate Towards ‘tau tangles’, which is the Alzheimer’s biomarker.
For those mR-mutated mice with a high-fat diet, it was a much worse problem. They were more prone to obesity, glucose intolerance and insulin resistance Depression And anxiety-like behaviors and their brains showed more of a tendency to develop Alzheimer’s disease.
Our results show that a high-fat diet facilitates the development of insulin resistance and increases cognitive changes and pathology in pR5 transgenic mice. The researchers write.
“The consequences of high-fat dietary pathology are ultimately exacerbated by a lack of awareness in these mice.”
This may seem a bit of a concern. 42% of adults Obese Americans or 37 million Americans with type 2 diabetes but understanding these factors – especially the use of new mouse models – is important for scientists to know. New treatments Or suggest scientifically supported changes.
“Our findings underscore the importance of addressing global obesity Infectious disease. The combination of obesity, old age and diabetes has a high risk of cognitive impairment, Alzheimer’s disease and other mental health disorders. Says Boborovskaya.
The study was published in Metabolic Brain Disease.