According to Israeli scientists, partial modification of weak electrical currents in the brain can be used to treat Parkinson’s disease.

Their research, peer reviewed and say Published in the NJP Journal of Parkinson’s Disease, It could open up a new way to fight the disease and make it possible for people to be diagnosed at a younger age.

A major problem in developing a drug for Parkinson’s is that although it is defined as one disease, many scientists think of it as a term for many diseases with common characteristics.

The genetic mutation underlying Parkinson’s has been identified in only about 15 percent of cases. Because of this, scientists struggle to find common – or in medical jargon – behaviors in the brains of Parkinson’s patients that can be targeted with drugs.

Dr. Shani Stern, a neurologist at the University of Haifa, said in a study that patients with or without specific mutations all had reduced synaptic currents in certain areas of the brain compared to healthy individuals. . These are special waves that are created under synapses, which are the conductors between neurons.

The changes in the brain that Stern and her colleagues identified are “central to and associated with Parkinson’s disease,” Stern and her colleagues wrote in their study.

“We found mechanisms shared by all the Parkinson’s cases we examined. These are mechanisms that are not known to be related to Parkinson’s, and now we have new targets for which drugs can be developed in the future, which can make them look like healthy neurons,” she told The Times of Israel.

Image: Nerves in the human brain (courtesy of iStock via Getty Images)

If her current research identifies a link between synaptic currents and Parkinson’s, she hopes to develop a new strategy to fight the disease. Drugs may be developed that restore the currents to normal levels and, through this change, gradually slow down the progression of Parkinson’s disease.

The research method involves “reprogramming” brain cells into stem cells. Analysis was carried out on cells obtained from stem cells. This process allowed the scientists to see how the cells work at different ages, and they made a great discovery: even when the cells are young, the synaptic current is reduced.

Dr. Shani Stern of the University of Haifa (provided by Dr. Shani Stern)

Much more research is needed, Stern said, but their findings raise the possibility that young people with a family history of Parkinson’s may have sequenced cells that measure the size of synaptic currents. People who appear to be at risk for the disease may be given drugs that slow its progression — either current treatments or future releases.

“Our findings indicate that the changes are present in Parkinson’s patients long before they are aware of the disease process occurring in their brains.” If we do this sequence on a young person and get a picture similar to that of people with Parkinson’s disease, we can imagine that this individual will develop the disease over time.

“Currently, most treatments are aimed at slowing the progression of the disease rather than preventing it. If we can identify the risk of developing Parkinson’s disease at an early stage and develop treatments that stop the progression of the disease, we can start preventive treatment at a stage where neuronal cell death is limited. This can significantly reduce the development of the disease.

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