Study of female genital health

Best of all, it can be inoculated with different types of bacteria that allow researchers to study their effects on the body’s health.

“The vaginal microbiome plays an important role in regulating vaginal health and disease, and has a significant impact on prenatal health. Our human vaginal chip provides an exciting solution to study host-microbiome interactions and accelerate potential probiotic therapies,” said first author Gautam Mahajan. Ph.D., former Wis. Institute researcher now at Emulate, Inc.

The vagina-on-a-chip was developed with funding from the Bill & Melinda Gates Foundation to treat bacterial vaginosis (BV), a disruption of the vaginal microbiome.

By developing a biotherapeutic treatment for BV and moving it into human clinical trials, the organization hopes to reduce its many negative effects, such as reproductive tract infections, premature birth complications, and infant mortality, especially in low-resource countries.

Scientists have created the world's first 'Vagina-on-a-Chip' to prevent bacterial infections

The new chip helps with female genital health.

BV is currently treated with antibiotics, but it is often recurrent and can lead to serious complications, including inflammatory bowel disease and infertility.

“A major obstacle to that effort has been the lack of good preclinical models that can be used to study which treatments can effectively treat BV in human tissue. Our group’s project was to create a human vagina chip to help develop and test new treatments for BV,” said co-author Akansha Gulati, a postdoctoral researcher at the Wiss Institute. , said Ph.D.

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