History at a glance

  • According to 2020 data, Alzheimer’s disease will affect 5 million people in the United States.

  • Researchers are working to understand the various risk factors that contribute to the development of the disease.

  • Researchers have investigated the role of a newly identified microprotein in neuronal mitochondria.

A new study is revealing the role of a particular protein in the development of Alzheimer’s disease, which affects 5 million people in the United States, he reports. Assumptions From 2020

In a study published today Molecular psychiatryResearchers have identified a new gene from mitochondrial DNA that codes for a “microprotein” called SHMOOSE. They analyzed wild-type and mutated versions of this small protein and found that the mutated version is associated with Alzheimer’s disease, brain atrophy and changes in energy metabolism.

The recent discovery of SHMOOSE comes as some question its authenticity. Research on amyloid or plaques that form in the brain.

The team thinks that SHMOOSE, which they found in the mitochondria of neurons, is important for energy signaling and metabolism in the central nervous system. Microprotein levels in cerebrospinal fluid correlate with other symptoms of Alzheimer’s disease.

In an experiment, they administered SHMOOSE directly into the brain of mice and found evidence that the protein was active in it. HypothalamusThe part of the brain that produces hormones for body temperature, heart rate, and hunger. Further experiments in the laboratory using cultured cells confirmed that the non-converting forms of microproteins affect mitochondrial metabolism.

“This discovery opens up exciting new directions for the development of precision medicine-based therapies for Alzheimer’s disease by focusing on SHMOOSE as a target site,” said Pinchas Cohen, professor of gerontology, medicine and biological sciences and senior author of the study. press release. Administration of SHMOOSE analogs in individuals who carry the mutation and produce the mutant protein may benefit neurodegenerative and other diseases of aging.

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