The three biggest differences between plants and animals are that animals have a nervous system, movement, and cholesterol.

In recent years, the pharmaceutical industry has painted cholesterol as the root of all evil, saying that if your cholesterol is above a certain level, you are at high risk and should take X number of precautions and Y number of drugs, he said.

It is one class of medicine that has become particularly popular in the last few decades. statins. Statins are a type of enzyme inhibitor, which means they interfere with biological processes in the body.

Statins lower HMG. They prevent coenzyme A reductase from functioning normally, a critical step in a long chain of reactions that leads to the production of many important fats and molecules in the body, including cholesterol. HMG Blocking coenzyme A is how statins lower cholesterol.

The essential nature of cholesterol

So what does cholesterol do? Cholesterol is an important lipid found in humans and animals. It facilitates a well-functioning nervous system and effective mobility.

Cholesterol is found in areas of accumulation called “lipid rafts” on cell walls and is also dispersed throughout. “Rafts” help a lot in nutrient and ion transport, and dispersed cholesterol is a big help for muscle contraction and function.

Cholesterol is a precursor to many important hormones in the human body, including vitamin D3, sex hormones, and adrenal gland steroids. Positively or negatively charged particles such as sodium and potassium prevent the flow of ions across the cellular membrane. Cholesterol regulates bile acid levels.

And while the brain makes up 2 percent of the body’s weight, it does It takes about a quarter The amount of cholesterol in the body.

An Text Published by Norbert Kucerka et al. He summarized the role of cholesterol in a few sentences in the Journal of the American Chemical Society.

“Cholesterol is found in all animal cell membranes and is required for proper membrane coverage and fluidity. It is essential for building and repairing cell membranes, and can act as an antioxidant. Recently, cholesterol has also been implicated in cell signaling processes, and has been suggested to enable the formation of lipid rafts in the plasma membrane.”

Now, you can see that in order for our cells to function properly, we need cholesterol. But we don’t do it like Big Pharma.

Cholesterol and LDL

You may have heard about LDL before. LDL refers to low-density lipoprotein, which is made of cholesterol and a protein called “apoB,” among other molecules. But LDL is not a type of cholesterol, just like a steering wheel is not a car. LDL transports many important molecules in the body, such as cholesterol itself, vitamin D, and antioxidants. Low LDL usually means reduced bioavailability of these nutrients.

LDL is made in the liver and after the LDL particles have shed their contents, they are returned to the liver. Once their contents are delivered, LDL becomes “small dense LDL particles,” which are recycled by the liver.

Now remember the “ApoB” protein mentioned above? The apoB protein is particularly vulnerable to attacks by blood sugars such as glucose and especially fructose. Once sugar binds to apoB proteins in the bloodstream, the total LDL particle becomes more efficient at delivering its content and sticks around longer, increasing LDL serum levels. This is especially true for diabetics.

Glycated LDL particles (with sugars attached) not only take longer to do their job, but also have trouble being recycled by the liver. Ultimately, macrophages, part of the immune system, must seek to digest and recycle these rogue, glycated LDL particles.

of The liver has its job Fructose and other sugars in the blood are converted to fats (such as cholesterol, vitamin D, and hormones) and packaged into LDL particles that are transported around the body. However, the excessive amount of sugar in the blood interferes with this process and leads to the production of low-quality LDL by the liver. “Poor” LDL is less protective of cholesterol and is more likely to be affected by blood sugar. The liver cannot meet the demand for cholesterol required for LDL production and fructose conversion and a vicious cycle ensues.

Statin therapy treatments

Statins directly inhibit the production of cholesterol, which means that the liver no longer has the opportunity to convert blood sugar into fat. Fructose, in particular, remains in the blood and continues to damage proteins.

The biological chain reaction that statins stop produces not only cholesterol but also coenzyme Q10. Therefore, statistics have a significant impact on energy production.

Due to insufficient coenzyme Q10 and cholesterol, the muscles now face several issues. Ions flow out of muscle cells because cholesterol can’t stop it. The liver cannot continue the transformation of fructose due to the lack of cholesterol. There is a lot of sugar in the blood that causes oxidative damage to muscle cells.

Mitochondria in the body struggle with energy production because they lack coenzyme Q10, not to mention less LDL is generally sent from the liver, so cells receive less fat for fuel.

Everything we do is based on energy. The cells use energy not from a wall socket, but from a molecule called adenosine triphosphate, or ATP. The synthesis of ATP from sugar occurs in two stages: anaerobic (without oxygen) and aerobic (with oxygen). Anaerobic action produces two ATP molecules, while aerobic action usually yields between 32 and 36 ATP molecules.

Now, guess which step uses coenzyme Q10? That’s right, the more important aerobic activity.

Although the muscle cells of people taking statins have lost coenzyme Q10 and are therefore not capable enough to use aerobic ATP synthesis, they can still generate energy – very efficiently.

It’s like driving a car with square wheels instead of round ones. With the dominance of anaerobic action in the synthesis of ATP, the liver, struggling with the issue of fructose, completely eliminates the production of fructose in the muscles. Now, muscles are working overtime to efficiently produce ATP from fructose and convert it to lactose, a molecule the healthy heart can use as an alternative fuel source.

Stephanie Seneff, a senior research scientist at the Massachusetts Institute of Technology, says in her Paper “She explains how statins actually work and why they don’t,” she believes. “

“It’s well known that exercise is good for the heart,” she said. “In fact, I believe the reason exercise is good is the same reason statins are good: It provides the heart with lactate, which does not glycate very healthy cell proteins.”

But a low supply of cholesterol is still a terrible thing, because cells, especially muscle cells, have a number of fatal defects that occur when there is a lack of cholesterol. As mentioned earlier, cholesterol is an important part of the cellular membrane. Here, cholesterol acts as a gatekeeper on the phospholipid bilayer that covers each cell, preventing the flow of potassium and sodium.

In the absence of cholesterol, potassium and sodium naturally diffuse across the cell membrane due to their relative concentration gradients. A high concentration of sodium on one side of the cell causes it to flow to the side where there are not many sodium particles; The same is true for potassium.

This balancing effect found in all natural and biological systems is called homeostasis or equilibrium. Cholesterol prevents this process and facilitates its concentration on the cellular membrane; As a result, the muscles break down and move properly ion gradient. Here, cholesterol is likened to a hydroelectric dam.

Cholesterol levels dropped significantly during statin therapy. In vitro studies on phospholipid membranes show that removing cholesterol from the membrane increases potassium levels 19-fold. Flow rateAnd the amount of sodium is three times higher.

For muscles to move, we need this ion gradient, and to create this gradient, our cells need energy. But due to statistics, mitochondria are underperforming, so energy is very low.

The cells are now forced to efficiently produce more ATP molecules to maintain sufficient ion flux to maintain muscle activity. You might think it’s just our muscles that work a little harder, so what? Well, they are completely destroyed in the process.

Remember, the circulation under statin therapy contains surprisingly high levels of sugar molecules, especially fructose. Fructose is about 10 times More powerful Instead of glucose, the “normal” fuel used for the synthesis of ATP, for gluing proteins, which means that the muscles are now disintegrated due to the lack of protection from cholesterol, the lack of coenzyme Q10 as a powerful antioxidant and the abundance of fructose. Debris from dying muscle cells is carried through the bloodstream and sent to the liver in abnormally large amounts for recycling, putting it under extraneous stress.

Once more muscle cells are damaged, they can’t keep up with fructose-generating metabolism and struggle to produce enough energy for the heart and other muscles. The lack of muscle cells exposes the involved nerve endings and makes them vulnerable to injury. This can eventually lead to amyotrophic lateral sclerosis (if so)Or Lou Gehrig’s disease.

ALS belongs to the category of neurodegenerative diseases, which means that the development of dementia and neurological diseases can now be related to statin therapy, although the science is controversial. Memory loss is an accepted side effect of statin therapy.

In 2004 Research On the popular statin atorvastatin, he said, “statistical treatment worsened diastolic parameters,” meaning that diastolic heart failure was more likely.

One of the reasons for this, as estimated by Senef, is the lack of membrane cholesterol due to statin treatment. The cell, unable to keep up with the influx of sodium and potassium ions, replaces them with a system based on calcium and magnesium, but since they are ions, they are too large to “slide” or diffuse across the cellular membrane. These two substitutes don’t require cholesterol as a gatekeeper, because they don’t “get through the gate.”

Senef calcium and magnesium somehow do the job, but they are As a result In the arteries of the heart (calcification), which cause long-term heart failure.

Why should we be careful about using statins?

Cholesterol is very important for humans. Statins inhibit cholesterol production. From these two sentences, you might ask why statins are so widely prescribed to patients.

Although the use of statistics has increased over the past few decades and has become very profitable for the pharmaceutical industry, questions about the underlying rationale behind their benefits remain unanswered.

Senef, when answering the claims 2006 study “Statins cut the incidence of heart attacks by a third,” he said Her paper Because “heart attacks were rare among them. [the] group [of people in this study] This translates in absolute terms to 60 patients needing to be treated for an average of 4.3 years to protect one from one heart attack. However, they all basically experience weakness and mental decline [due to statin therapy]He said.

Statins remove cholesterol and coenzyme Q10 from the body, causing muscle cells to lose energy, leaky, and deteriorate.

Statins also flood the liver with high levels of sugar and force muscle cells to sacrifice themselves by processing fructose and producing energy in a self-destructive manner in order to efficiently deal with blood sugar and energy issues.

This process is anti-aging in the long term and increases the risk of diastolic heart failure, not least exposing nerve endings to muscle cells, which can have many consequences for the central nervous system.

Therefore, statins are drugs that should be carefully considered before taking them.

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