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SEOUL, South Korea — Yoshinobu Yamamoto lasted one inning in his Los Angeles Dodgers debut after signing a $325 million, 12-year contract and gave up five runs in a 15-11 loss to the San Diego Padres on Thursday.

Trailing 2-0 after nine pitches, the 25-year-old right-hander needed 43 pitches to get three outs, giving up a 45.00 ERA.

San Diego batted, and Michael Grove relieved Yamamoto to give the Dodgers a 5-1 win.

Yamamoto (0-1) allowed four hits, walked one, hit a batter and threw a wild pitch. He threw just 23 pitches for strikes, with his fastball averaging 95.4 mph. He attempted 14 fastballs, 11 cutters, 10 curveballs and eight splits.

Xander Bogaerts hit a 96.6 mph fastball up the middle of the pitch to left field. Fernando Tatis Jr. split the count and Jake Kronenwerth tripled into the right field corner for a 2-0 lead.

Manny Machado walked 15 pitches before the mound, bringing up pitching coach Mark.

Ha-Seong Kim hit a sacrifice fly, advanced Machado on a wild fly and Jurickson Profar hit on an inside cutter.

Luis Campusano hit a third-base bouncer that went under the glove of Max Muncy and went down the line for an RBI double and a 4-0 lead. Tyler Wade hit a run-scoring single to right and starter Jackson Merrill followed on an inside curveball.

The Dodgers allowed five runs in the first inning just once last season.

Yamamoto was a two-time Pacific League MVP for the Oryx Buffaloes in Japan. In December, he signed a contract with the Dodgers, the largest amount guaranteed to a pitcher.